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This website provides curated access to Cardio‑SM (Cardio‑Specifications Matcher), a decision support tool aimed to promote the standardization of variant interpretation and disseminate knowledge.
Cardio‑SM applies the ACMG/AMP guidelines (Richard et al., 2015) incorporating the ClinGen Cardio VCEP Specifications, released in April 2024.
By prompting you to enter relevant data and/or answer targeted conceptual questions, this tool can guide you comprehensively through the criteria assignment process
Supported Genes: MYH7, MYBPC3, TNNI3, TNNT2, TPM1, ACTC1, MYL2, MYL3 on MANE Select transcripts